What possible complication might arise while using methadone for treating OUD?

QTc prolongation is a known potential complication of methadone use in the treatment of Opioid Use Disorder (OUD). Methadone is a long-acting opioid that can affect cardiac repolarization, leading to an extended QT interval on an electrocardiogram (ECG). This prolongation can increase the risk of life-threatening arrhythmias, such as Torsades de Pointes, particularly when used in high doses or in patients receiving other medications that also prolong the QT interval.

This side effect underscores the need for careful monitoring of the ECG in patients undergoing treatment with methadone, especially if they have other risk factors for cardiac issues. It highlights the importance of understanding the pharmacodynamics of methadone and emphasizes the need for ongoing patient follow-up and management to mitigate potential risks associated with its use. Frequent cardiac monitoring and evaluation of risk factors can help in ensuring patient safety during treatment with methadone.